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The Elemental Health Institute (EHI), founded by MSU Foundation Professor Tom O’Halloran, will facilitate the ability of diverse research teams to apply recent breakthroughs in understanding how cells concentrate and use essential and toxic elements. Fluctuations in both total cellular content and subcellular localization have been shown to control processes as varied as the mammalian cell cycle, pathogen infection, and neurological function.  EHI members will create new technologies that stimulate fundamental and applied research across many areas of biology, such as embryonic development, biomarkers, evolution, plant physiology, neurobiology, host-pathogen interactions, cell state transitions, metabolism, and environmental toxicities.

To ensure synergy and coordination of EHI initiatives the Institute will include current MSU faculty who are internationally recognized leaders in their fields in the College of Natural Science, College of Engineering, CHM, COM, AgBioResearch, FBIR, CVM, CANR to identify, recruit, and hire interdisciplinary faculty candidates with research interests across the broad interface of inorganic physiology. The Elemental Health Institute will bring together interdisciplinary teams to solve these problems. In its first year, EHI has brought over $3M of new NIH grant awards into the MSU research community.


 

EHI CENTERS

QBEAM

The Quantitative Bio Element Analysis and Mapping (QBEAM) Center was founded by Professor Thomas V. O’Halloran at MSU in January of 2021 as an interdisciplinary center within EHI focused on examining elemental quotas in biology from single cells to whole organisms and how the interplay between metals and systems biology can be harnessed to develop therapeutics, elucidate the mechanisms of disease, and further our understanding of the ecological and environmental consequences of metal exposure. We accomplish this using a multitude of trace element analysis equipment including ICP-MS, ICP-OES, LA-ICP-TOF-MS, HPLC, IC, and combustion analysis.

QBEAM

QE-MAP

National Research Resource for Quantitative Elemental Mapping in the Life Sciences (QE-Map) is a NIH NIGMS P41 funded resource focused on the development of novel analytical and imaging technologies that enable biomedical research teams to image changes in metal localization in a quantitative manner from the cellular level to tissue and whole animal. The QE-Map will integrate multiple technologies to create transformative approaches to answer compelling biological questions about the functions of metals and other essential elements in health and disease.

QEMAP